When her father dies unexpectedly, Dr. Ayne Amjad is thrust to the helm of a decades-long struggle to aid Minden, a southern West Virginia town beset by cancer-causing chemicals. Ayne is caught between her dream of raising a family and an audacious but all-consuming plan to relocate the town and bring closure to her father's work. After encountering initial resistance, Ayne takes her ambitions statewide, landing a high-profile role as WV's state health officer. But the demands of her new position make it all but impossible to pursue her goal of moving Minden. When a legal gambit to hold an industry titan accountable reveals new information about the community, Ayne must decide how much she's willing to sacrifice to help the people of Minden achieve their goals.